Copper(I)-promoted trifluoromethylation of indole derivates with concomitant C-C bond formation to access fused tricyclic indoles

Modern drug discovery has created an increasing demand for new methods of trifluoromethylation. Herein a novel method for the synthesis of trifluoromethylated fused tricyclic indoles by copper(I) iodide as catalyst has been successfully developed under mild conditions. The corresponding trifluoromethyl indoles were obtained with good to excellent yields (62-89%) and the reaction applies to a different range of functional groups. (C) 2015 Elsevier Ltd. All rights reserved.