4.4 Article

α-(N-Sulfonyl)amino amides from a carbamoylsilane and N-sulfonylimine

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 11, Pages 1335-1337

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.01.196

Keywords

Sulfonylimines; Carbamoylsilane; Amides; Addition; Synthetic methods

Funding

  1. Shanxi Province Foundation for Returness [0713]
  2. Natural Science Foundation of Shanxi Province [2012011046-9]
  3. Foundation of Shanxi Normal University, China [SD2014CXXM-53]

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Under using anhydrous benzene as a solvent, and no catalyst, N,N-dimethylcarbamoyl (trimethyl)silane reacts with N-sulfonylimines at 60 degrees C to afford alpha-(N-sulfonyl)amino amides derivatives in good yields (71-89%). The electronic property of the substituted group on the aryl ring affects the reaction. (C) 2015 Elsevier Ltd. All rights reserved.

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