Journal
TETRAHEDRON LETTERS
Volume 56, Issue 17, Pages 2123-2132Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.03.065
Keywords
Bioorthogonal organic chemistry; Ligand-directed organic chemistry; Protein labeling and engineering
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Funding
- National Natural Science Foundation of China [31470749]
- 'Thousand Talents Program' young investigator award of China
- Shanghai Rising Star Scholar award [13QA1404300]
- start-up fund from State Key Laboratory of Bioorganic and Natural Products Chemistry
- Chinese Academy of Sciences
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In the past two decades, with the rapid development of chemical biology, tremendous small-molecule based toolkits were created by organic chemists, and were widely used to study and manipulate proteins in order to dissect their complicated biological functions. This review summarizes some recent progresses of bioorthogonal reactions for site-specific protein labeling and engineering, and highlights the powers of using these methods to study the biological functions of some proteins. (C) 2015 Published by Elsevier Ltd.
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