Journal
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
Volume 27, Issue 4, Pages E87-E88Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IOP.0b013e3181ef72a1
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Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease.
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