4.4 Article

Convenient copper-mediated Chan-Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 33, Pages 4843-4847

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.06.092

Keywords

Heterocycles; Chan-Lam coupling; Copper catalyst; Pyridine; Aryl boronic acid

Funding

  1. state of Mecklenburg-Vorpommern
  2. Bundesministerium fur Bildung und Forschung (BMBF)
  3. Deutsche Forschungsgemeinschaft

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A new and practical process for the synthesis of N-arylpyridin-2-amine derivatives has been developed. Under the assistance of copper, the desired products were produced from commercially available 2-aminopyridine and aryl boronic acids in moderate to good yields with good functional group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.

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