4.4 Article

Copper mediated oxidative coupling between terminal alkynes and CuCN

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 2, Pages 390-392

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.11.108

Keywords

Iron; Cyanoalkyne; Oxidative coupling; Terminal alkyne

Funding

  1. National Natural Science Foundation of China [21202050]
  2. Natural Science Foundation of Hubei Province of China [2014CFB930]

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A direct oxidative cross coupling between terminal alkynes and CuCN to form 1-cyanoalkynes was reported. FeCl3 was employed as the sole additive. The reaction could be carried out under mild conditions, with moderate to good yields. (C) 2014 Published by Elsevier Ltd.

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