Journal
TETRAHEDRON
Volume 71, Issue 39, Pages 7459-7469Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.06.052
Keywords
Dieckmann cyclisation; Piperidine-2,4-diones; Regioselective synthesis; Enantioselective synthesis
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A flexible route to piperidine-2,4-diones variously substituted at the 6-, 5,6- and 2,6-positions, both with and without 1-substitution, is described; no N-protective group is required. A related regioselective Dieckmann cyclisation is also described that uses Davies' alpha-methylbenzylamine auxiliary and affords 6-substituted piperidine-2,4-diones enantioselectively. (C) 2015 Elsevier Ltd. All rights reserved.
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