beta-Adrenergic Receptors in Cancer: Therapeutic Implications

The beta adrenergic receptors transduce catecholamine signals to the G protein which through a cascade of chemical reactions in cells generates highly specific parallel signals The beta 2 adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes Previous studies have determined the relationship of ADRB2 with various aspects related to cancer Basically, it seems to be related with cell proliferation and apoptosis chemotaxis development of metastasis and tumor growth and angiogenesis The purpose of this review is to update the implications of these receptors in the pathogenesis of cancer and study the possible application of agonist drugs and/or antagonists in antitumor therapy