Journal
ONCOLOGY REPORTS
Volume 31, Issue 3, Pages 1343-1349Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2013.2933
Keywords
epigallocatechin gallate; epidermal growth factor receptor; lung cancer
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Funding
- Nature Scientific Foundation of China [81371690]
- Nature Scientific Foundation of Hunan Province [08JJ6010]
- Research Program of the Science and Technology Department of Hunan Province [2012FJ4076, 2012TT2011]
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Epigallocatechin gallate (EGCG), the major biologically active compound in green tea, is a well-known chemoprevention agent. Although several reports have shown that EGCG exerts its anticancer activity by targeting specific cell signaling pathways, the underlying molecular mechanism(s) are only partially understood. In the present study, we report that EGCG had a profound antiproliferative effect on human lung cancer cells. EGCG inhibited anchorage-independent growth and induced cell cycle G(0)/G(1) phase arrest. The mechanism underlying EGCG antitumor potency was mainly dependent on suppression of the EGFR signaling pathway. Short-term EGCG exposure substantially decreased EGF-induced EGFR, AKT and ERK1/2 activation. Moreover, long-term EGCG treatment not only inhibited total and membranous EGFR expression, but also markedly attenuated EGFR nuclear localization and expression of the downstream target gene cyclin D1, indicating that EGCG treatment suppressed EGFR transactivation. Additionally, knockdown of EGFR in lung cancer cells decreased their sensitivity to EGCG. Thus, inhibition of the EGFR signaling pathway may partly contribute to the anticancer activity of EGCG.
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