Journal
ONCOLOGY REPORTS
Volume 29, Issue 5, Pages 1902-1906Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2013.2332
Keywords
lung adenocarcinoma; prognostic factor; microarray; molecular pathway analysis; early relapse; cell adhesion molecule
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Funding
- Ministry of Education, Culture, Sports, Science and Technology [21791332]
- Grants-in-Aid for Scientific Research [21791332] Funding Source: KAKEN
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Clinicohistopathological staging is insufficient to predict disease progression and clinical outcome in lung carcinoma. Based on the results of the principal component analysis of 24 samples of early-stage lung adenocarcinoma, two subgroups were identified within the early-relapse group. The histological classification of all samples of group A was poorly differentiated, whereas one out of three in group B was poorly differentiated. DAVID functional annotation analysis revealed that the molecular pathways enriched in group A included those associated with cell adhesion molecules (CAMs), cell cycle and antigen processing and presentation, whereas those in group B included CAMs, T cell receptor signaling, cytokine-cytokine receptor interaction, toll-like receptor signaling, chemokine signaling, primary immunodeficiency and natural killer cell-mediated cytotoxicity. The CAM pathway was enriched in both groups. This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma.
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