Journal
TETRAHEDRON
Volume 71, Issue 21, Pages 3247-3252Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.03.116
Keywords
alpha-Hydroxyketones; CuBr2; HBr; DMSO
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Funding
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [21172068]
- Shanghai Committee of Science and Technology [14431902500]
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An efficient and facile alpha-hydroxylation of ketones catalyzed by CuBr2 or HBr in DMSO is developed, providing secondary/tertiary alpha-hydroxy carbonyl compounds in moderate to good yields (up to 87%). A series of control experiments suggested that water and DMSO may work cooperatively in the hydrolysis step. (C) 2015 Elsevier Ltd. All rights reserved.
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