Journal
ONCOLOGY REPORTS
Volume 24, Issue 5, Pages 1363-1369Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or_00000994
Keywords
microRNA; miR-143; apoptosis; Bcl-2; osteosarcoma
Categories
Funding
- National Natural Science Foundation of China [30973019]
Ask authors/readers for more resources
Deregulated microRNAs and their roles in tumorigenesis are still largely unknown. Here, we focused on the roles of miR-143 in osteosarcoma, as previous reports have suggested its importance in some other types of cancer. We found that miR-143 was down-regulated in osteosarcoma cell lines and primary tumor samples, and the restoration of miR-143 reduced cell viability, promoted cell apoptosis and suppressed tumorigenicity. Additionally. Bcl-2, an important antiapoptotic molecule, was identified to be a novel direct target of miR-143, and the proapoptotic function of miR-143 is further suggested to be mainly through the targeting of Bcl-2 expression. Collectively, our data identify the important roles of miR-143 in osteosarcoma pathogenesis and indicate its potential application in cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available