Journal
ONCOLOGIST
Volume 17, Issue 7, Pages 891-899Publisher
ALPHAMED PRESS
DOI: 10.1634/theoncologist.2012-0039
Keywords
Inflammatory breast cancer; Systemic therapy; Targeted therapy
Categories
Funding
- Morgan Welch Inflammatory Breast Cancer Research Program and Clinic
- University of Texas MD Anderson Cancer Center
- National Institutes of Health [R01-CA123318, CA016672]
- State of Texas Rare and Aggressive Breast Cancer Research Program Grant
- Novartis
- Amgen
- Celgene
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Purpose. We review the current status of multidisciplinary care for patients with inflammatory breast cancer (IBC) and discuss what further research is needed to advance the care of patients with this disease. Design. We performed a comprehensive review of the English-language literature on IBC through computerized literature searches. Results. Significant advances in imaging, including digital mammography, high-resolution ultrasonography with Doppler capabilities, magnetic resonance imaging, and positron emission tomography-computed tomography, have improved the diagnosis and staging of IBC. There are currently no established molecular criteria for distinguishing IBC from noninflammatory breast cancer. Such criteria would be helpful for the diagnosis and development of novel targeted therapies. Combinations of neoadjuvant systemic chemotherapy, surgery, and radiation therapy have led to an improved prognosis; however, the overall 5-year survival rate for patients with IBC remains very low (similar to 30%). Sentinel lymph node biopsy and skin-sparing mastectomy are not recommended for patients with IBC. Conclusion. Optimal management of IBC requires close coordination among medical, surgical, and radiation oncologists, as well as radiologists and pathologists. There is a need to identify molecular changes that define the pathogenesis of IBC to enable eradication of IBC with the use of IBC-specific targeted therapies. The Oncologist 2012;17: 891-899
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