Concise synthesis of binaphthol-derived chiral dicarboxylic acids

3,3'-Disubstituted 1,1'-binaphthy1-2,2'-dicarboxylic acids (1) were synthesized in three or four steps from commercially available BINOL via carbon dioxide fixation with organolithium to incorporate the carboxylic acid moieties, followed by either carboxylate-directed ortho-C-H arylation or Suzuki cross-coupling. This method provides easy access to various types of axiially chiral dicarboxylic acids, which should be useful for studies of chiral Bronsted acid-catalyzed asymmetric reactions. (C) 2015 Elsevier Ltd. All rights reserved.