Journal
ONCOLOGIST
Volume 14, Issue 10, Pages 979-985Publisher
ALPHAMED PRESS
DOI: 10.1634/theoncologist.2009-0079
Keywords
Fibrinogen; Ovarian cancer; Prognosis; Inflammation; Plasma
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Introduction. To evaluate pretherapeutic plasma fibrinogen levels as a prognostic parameter in patients with epithelial ovarian cancer (EOC). Materials and Methods. In the present multicenter study, pretherapeutic plasma fibrinogen levels were evaluated in 422 patients with EOC. Plasma fibrinogen levels were correlated with clinicopathological parameters and patient survival. Results. The mean (standard deviation) pretherapeutic plasma fibrinogen level was 450.0 (150.1) mg/dl. El-evated plasma fibrinogen levels were associated with advanced tumor stage (p = .01) and the presence of a postoperative residual tumor mass (p < .001), but not with histological grade (p = .1) and histological type (p = .8). In a multivariate Cox regression model, tumor stage (p < .001 and p < .001), postoperative residual tumor mass (p = .001 and p = .008), and plasma fibrinogen level (p < .001 and p = .002), but not histological type (p = .8 and p = .2), patient age (p = .9 and p = .9), and serum cancer antigen 125 (p = 0.2 and p = 0.3) and C-reactive protein (p = .2 and p = .3) levels, were associated with disease- free and overall survival, respectively. Histological grade was associated with overall but not with disease- free survival (p = .01 and p = .8), respectively. Conclusions. Pretherapeutic plasma fibrinogen levels can be used as an independent prognostic parameter in patients with EOC. The Oncologist 2009; 14: 979-985
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