Journal
ONCOLOGIST
Volume 14, Issue 11, Pages 1070-1082Publisher
WILEY
DOI: 10.1634/theoncologist.2009-0094
Keywords
Circulating tumor cells; Breast cancer; Colon cancer; Prostate cancer
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Circulating tumor cells (CTCs) are rare malignant cells found in the peripheral blood that originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterize these cells. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. This review covers the different techniques available for isolation of CTCs, the clinical utility of CTCs in breast, prostate, and colon cancer, and future directions in this field. The Oncologist 2009;14:1070-1082
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