Journal
ONCOLOGIST
Volume 13, Issue 12, Pages 1285-1295Publisher
ALPHAMED PRESS
DOI: 10.1634/theoncologist.2008-0130
Keywords
Neurotoxicity; Cognitive dysfunction; Chemotherapy; Radiation therapy; Progenitor cells; Neural stem cells
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Standard oncological therapies, such as chemotherapy and cranial radiotherapy, frequently result in a spectrum of neurocognitive deficits that includes impaired learning, memory, attention, and speed of information processing. In addition to classical mechanisms of neurotoxicity associated with chemo- and radiotherapy, such as radiation necrosis and leukoencephalopathy, damage to dynamic progenitor cell populations in the brain is emerging as an important etiologic factor. Radiation- and chemotherapy-induced damage to progenitor populations responsible for maintenance of white matter integrity and adult hippocampal neurogenesis is now believed to play a major role in the neurocognitive impairment many cancer survivors experience. The Oncologist 2008; 13: 1285-1295
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