Convenient stereoselective synthesis of β-perfluoroalkyl α,β-unsaturated esters via Horner-Wadsworth-Emmons reactions

Condensation of Horner-Wadsworth-Emmons reagents 3 and ketones 2 with a perfluoroalkyl (Rf) moiety prepared in situ was proved to be significantly efficient and powerful methods for the construction of a wide variety of alpha,beta-unsaturated esters with Rf and R-1 groups both at the beta-position due to convenient avoidance of usually tedious as well as troublesome isolation steps of these ketones 2. (C) 2015 Elsevier Ltd. All rights reserved.