Journal
ONCOGENE
Volume 33, Issue 7, Pages 933-938Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2013.37
Keywords
chromatin remodeling; tumor suppressor; Swi/Snf; beta-catenin; epigenetics
Funding
- National Cancer Institute, National Institutes of Health [1F31CA130553, R01CA113794, U01-1156106]
- Stand Up 2 Cancer Innovative Research Grant
- The Garrett B Smith Foundation
- Cure AT/RT
- Miles for Mary
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The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies beta-catenin hyperactivation and that SNF5 is essential for regulating Wnt/beta-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.
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