Journal
ONCOGENE
Volume 33, Issue 4, Pages 403-410Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2013.56
Keywords
MEF2C; hematopoiesis; leukemia
Funding
- Children Cancer Free Foundation (Stichting Kinderen Kankervrij (KIKA) [2008-029]
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MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.
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