Journal
ONCOGENE
Volume 31, Issue 49, Pages 5081-5089Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.15
Keywords
miR-9; cytokines; Hodgkin lymphoma; HuR; DICER1
Funding
- Danish National Advanced Technology Foundation
- EC FP7 ONCOMIRS consortium [201102]
- Novo Nordisk Foundation
- Lundbeck Foundation
- Danish Cancer Society
- Danish National Research Foundation
- Monte dei Paschi di Siena Foundation
- Danish Medical Research Council
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MicroRNAs are important regulators of gene expression in normal development and disease. miR-9 is overexpressed in several cancer forms, including brain tumours, hepatocellular carcinomas, breast cancer and Hodgkin lymphoma (HL). Here we demonstrated a relevance for miR-9 in HL pathogenesis and identified two new targets Dicer1 and HuR. HL is characterized by a massive infiltration of immune cells and fibroblasts in the tumour, whereas malignant cells represent only 1% of the tumour mass. These infiltrates provide important survival and growth signals to the tumour cells, and several lines of evidence indicate that they are essential for the persistence of HL. We show that inhibition of miR-9 leads to derepression of DICER and HuR, which in turn results in a decrease in cytokine production by HL cells followed by an impaired ability to attract normal inflammatory cells. Finally, inhibition of miR-9 by a systemically delivered antimiR-9 in a xenograft model of HL increases the protein levels of HuR and DICER1 and results in decreased tumour outgrowth, confirming that miR-9 actively participates in HL pathogenesis and points to miR-9 as a potential therapeutic target. Oncogene (2012) 31, 5081-5089; doi:10.1038/onc.2012.15; published online 6 February 2012
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