Journal
ONCOGENE
Volume 32, Issue 38, Pages 4572-4578Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.470
Keywords
Sgk1; RANBP1; taxol sensitivity; mitotic microtubule stabilization
Funding
- Italian Association for Cancer Research (AIRC) [IG10164]
- INAIL, CZ
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The serum- and glucocorticoid-regulated kinase (Sgk1) is essential for hormonal regulation of epithelial sodium channel-mediated sodium transport and is involved in the transduction of growth factor-dependent cell survival and proliferation signals. Growing evidence now points to Sgk1 as a key element in the development and/or progression of human cancer. To gain insight into the mechanisms through which Sgk1 regulates cell proliferation, we adopted a proteomic approach to identify up- or downregulated proteins after Sgk1-specific RNA silencing. Among several proteins, the abundance of which was found to be up- or downregulated upon Sgk1 silencing, we focused our attention of RAN-binding protein 1 (RANBP1), a major effector of the GTPase RAN. We report that Sgk1-dependent regulation of RANBP1 has functional consequences on both mitotic microtubule activity and taxol sensitivity of cancer cells.
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