Journal
ONCOGENE
Volume 32, Issue 27, Pages 3306-3310Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.372
Keywords
breast cancer; IGF2; miR-100
Funding
- FWF
- Austrian Government's GENAU program
- IMBA
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Dysregulation of micro RNAs is crucially implicated in tumorigenesis. We detected downregulation of miR-100 in breast cancer cells, leading to an upregulation of the proliferation- and survival-promoting oncogene insulin-like growth factor (IGF) 2. Stable overexpression of miR-100 strongly reduced IGF2 expression and inhibited tumor growth. In invasive human breast tumors, miR-100 was reduced about fourfold as compared with benign patient samples, whereas IGF2 was strongly enhanced. MiR-100 has also been shown to suppress other proteins of the IGF/mammalian target of rapamycin (mTOR) signaling cascade in different human tumors. Our results reveal miR-100 as a context-dependent master regulator of the IGF/mTOR pathway and a potential target for therapeutic approaches.
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