Journal
ONCOGENE
Volume 31, Issue 49, Pages 5045-5060Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.7
Keywords
cancer; apoptosis; necroptosis; autophagy; therapy
Funding
- Cancer Research UK
- Association for International Cancer Research
- Cancer Research UK [15816] Funding Source: researchfish
- Worldwide Cancer Research [09-0170] Funding Source: researchfish
Ask authors/readers for more resources
Cancer is a multifaceted disease comprising a combination of genetic, metabolic and signalling aberrations, which severely disrupt the normal homeostasis of cell growth and death. Many oncogenic events while promoting tumour development also increase the sensitivity of cells to cell death stimuli including chemotherapeutic drugs. As a result, tumour cells often acquire the ability to evade death by inactivating cell death pathways that normally function to eliminate damaged and harmful cells. The impairment of cell death function is also often the reason for the development of chemotherapeutic resistance encountered during treatment. It is therefore necessary to achieve a comprehensive understanding of existing cell death pathways and the relevant regulatory components involved, with the intention of identifying new strategies to kill cancer cells. This review provides an insightful overview of the common forms of cell death signalling pathways, the interactions between these pathways and the ways in which these pathways are deregulated in cancer. We also discuss the emerging therapies targeted at activating or restoring cell death pathways to induce tumour cell death, which are currently being tested in clinical trials. Oncogene (2012) 31, 5045-5060; doi: 10.1038/onc.2012.7; published online 6 February 2012
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available