Journal
ONCOGENE
Volume 29, Issue 24, Pages 3583-3592Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2010.106
Keywords
neuroblastoma; T-UCR; non-coding RNA
Funding
- Gent University [BOF 01D31406, BOF 01F07207, BOF 01Z09407]
- Belgian Kid's Fund
- Fondation pour la recherche Nuovo-Soldati
- RTICC/ISCIII [RD06/0020/0102]
- American Cancer Association
- Swedish Cancer Society
- Fund for Scientific Research [G.0198.08, 31511809]
- Belgian Foundation Against Cancer [SCIE2006-25]
- Fund for Scientific Research-Flanders
- Institute for the Promotion of Innovation by Science and Technology in Flanders [IWT - 081373]
- European Community [037260, 201102]
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Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010
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