Journal
ONCOGENE
Volume 29, Issue 23, Pages 3313-3323Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2010.109
Keywords
inflammation; colon cancer; chemokines
Funding
- Broad Medical Research Program,
- Italian Ministery of Health (Ricerca Finalizzata) [72]
- Bando Giovani Ricercatori
- Fondazione Cariplo
- Italian Association for Cancer Research (AIRC)
- European Community [518167]
- Ministero dell'Istruzione dell'Universita e della Ricerca (Rome, Italy) [2002061255, RBIN04EKC]
- Fondazione Cariplo (Milan, Italy)
- Fondazione Humanitas per la Ricerca (Rozzano, Italy)
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Colon cancer represents a paradigm for the connection between inflammation and cancer in terms of epidemiology and mechanistic studies in preclinical models. Key components of cancer promoting inflammation include master transcription factors (for example, nuclear factor kappa B, STAT3), proinflammatory cytokines (for example, tumor necrosis factor, interleukin-6 (IL-6)), cyclooxygenase-2 and selected chemokines (for example, CCL2). Of no less importance are mediators that keep inflammation in check, including IL-10, transforming growth factor beta, toll-like receptor and the IL-1 receptor inhibitor TIR8/SIGIRR, and the chemokine decoy and scavenger receptor D6. Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies. Oncogene (2010) 29, 3313-3323; doi:10.1038/onc.2010.109; published online 19 April 2010
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