Journal
ONCOGENE
Volume 29, Issue 42, Pages 5663-5666Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2010.334
Keywords
MUC1; MUC1-C subunit; nuclear localization; transcriptional regulation; Wnt/beta-catenin; p53
Funding
- NATIONAL CANCER INSTITUTE [R01CA097098, R01CA042802] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA097098-01, R01 CA097098, R01 CA042802, R01 CA042802-13] Funding Source: Medline
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The mucin 1 (MUC1) oncoprotein is overexpressed by diverse human cancers; however, it has remained largely unclear how MUC1 contributes to tumorigenesis. In this issue of Oncogene and in concert with published work, Behrens et al. report that the MUC1 receptor subunit activates genes involved in invasion, angiogenesis and metastasis. Oncogene (2010) 29, 5663-5666; doi:10.1038/onc.2010.334; published online 16 August 2010
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