Journal
ONCOGENE
Volume 28, Issue 14, Pages 1653-1668Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2009.4
Keywords
BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling
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The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
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