Journal
ONCOGENE
Volume 29, Issue 11, Pages 1580-1587Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2009.445
Keywords
let-7; microRNAs; lung cancer; K-ras
Funding
- NIH NRSA [F32CA130376]
- Ministry of Education and Science of Spain (MEC)
- Hope Funds for Cancer Research
- ASTRO
- NIH [CA131301-01A1]
- Connecticut Department of Public Health [2006-0913]
Ask authors/readers for more resources
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment. Oncogene (2010) 29, 1580-1587; doi:10.1038/onc.2009.445; published online 7 December 2009
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available