Journal
ONCOGENE
Volume 28, Issue 15, Pages 1769-1781Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2009.29
Keywords
apoptosis; NF-kappa B; TNF; TNFR1; TNFR2; TRAF1
Funding
- Deutsche Forschungsgemeinschaft [B7, HE 5275/2-1, Wa1025/8-1]
- IZKF Wurzburg [A-49]
- Weyth Biopharma
Ask authors/readers for more resources
It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NF kappa B and JNK. Here, we show that TRAF1 inhibits TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced activation of NF kappa B from the inhibitory effect of TNFR2. TRAF1 co-recruited with TRAF2 to both TNF receptors. Despite lackingan amino-terminal RING/zinc-finger domain, TRAF1 did not interfere with TNFR1-induced activation of JNK and NF kappa B. It is noted that physiological expression levels of TRAF1 enhanced NF kappa B activation and interleukin-8 (IL8) production induced by TNFR2. Thus, TRAF1 shifts the quality of integrated TNFR1-TNFR2 signaling from apoptosis induction to proinflammatory NF kappa B signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available