Journal
ONCOGENE
Volume 27, Issue 16, Pages 2300-2311Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2008.23
Keywords
FoxO; cell cycle; cancer; senescence; development; apoptosis
Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/03785] Funding Source: researchfish
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FoxO transcription factors are an evolutionary conserved subfamily of the forkhead transcription factors, characterized by the forkhead DNA-binding domain. FoxO factors regulate a number of cellular processes involved in cell-fate decisions in a cell-type-and environment-specific manner, including metabolism, differentiation, apoptosis and proliferation. A key mechanism by which FoxO determines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequence of FoxO deregulation is often manifested through perturbation of the cell cycle. Consequently, the deregulation of FoxO factors is implicated in the development of numerous proliferative diseases, in particular cancer.
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