Journal
ONCOGENE
Volume 27, Issue 50, Pages 6473-6488Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2008.313
Keywords
Akt/PKB; PI3K/PTEN; PDK2; mTORC; Akt-interacting proteins; human disease
Funding
- National Science Foundation [IOS-0757780]
- National Institutes of Health [RO1MH079439]
- G Harold & Leila Y Mathers Foundation
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The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.
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