Journal
ONCOGENE
Volume 27, Issue -, Pages S84-S92Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2009.46
Keywords
apoptosis; BH3-only proteins; p53
Funding
- Austrian Science Fund (FWF) [Y212-B13 START]
- Doctoral College MCBO [SFB021, P18747, P18571]
- Association for International Cancer Research (AICR) [EU-FP7]
- Austrian Science Fund (FWF) [P18571, P18747] Funding Source: Austrian Science Fund (FWF)
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Among all Bcl2 homology domain 3 (BH3)-only proteins known to date, APR/PMAIP1/Noxa, albeit showing weak proapoptotic potential on its own, appears to be crucial in fine-tuning cell death decisions by targeting the prosurvival molecule Mcl1 for proteasomal degradation. This event appears critical for cell death induction along the mitochondrial Bcl2-regulated apoptosis pathway in response to factor deprivation or DNA damage, presumably by sensitizing the cell toward the action of additional BH3-only protein family members. This review aims to summarize the function of Noxa in normal physiology, stress-induced cell death and tumorigenesis. Oncogene (2009) 27, S84-S92; doi: 10.1038/onc.2009.46
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