4.8 Review

BH3-only proteins in apoptosis and beyond: an overview

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

M. Vogler et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

E. M. Michalak et al.

CELL DEATH AND DIFFERENTIATION (2008)

Review Biochemistry & Molecular Biology

Exploiting BH3 only protein function for effective cancer therapy

Dean A. Fennell et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Article Biochemistry & Molecular Biology

Caspase cleavage of HER-2 releases a bad-like cell death effector

Anne M. Strohecker et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Huafeng Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death

Guanghua Wan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Immunology

Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

Masakatsu Yamashita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

Catherine L. Day et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Review Genetics & Heredity

The rationale for cardiomyocyte resuscitation in myocardial salvage

Gerald W. Dorn et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2008)

Article Biochemistry & Molecular Biology

Multisite phosphorylation regulates Bim stability and apoptotic activity

Anette Hubner et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

BAX activation is initiated at a novel interaction site

Evripidis Gavathiotis et al.

NATURE (2008)

Article Multidisciplinary Sciences

Essential role for Nix in autophagic maturation of erythroid cells

Hector Sandoval et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Nika N. Danial et al.

NATURE MEDICINE (2008)

Article Multidisciplinary Sciences

Antagonism of E2F-1 regulated Bnip3 transcription by NF-κB is essential for basal cell survival

James Shaw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins:: Comparative molecular dynamics simulations

Dilraj Lama et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)

Review Cell Biology

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Jerry E. Chipuk et al.

TRENDS IN CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Mai Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Rachel L. Schweers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cell Biology

Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

Bernhard Gillissen et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

dp5/HRK is a c-jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

Chi Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Medicine, Research & Experimental

Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice

Abhinav Diwan et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy

Kristin Tracy et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

BH3-only proteins trigger cytochrome c release, but how?

Georg Haeker et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Biochemistry & Molecular Biology

Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1

M. Chiara Maiuri et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Crystal structure of the Bcl-XL-beclin 1 peptide complex -: Beclin 1 is a novel BH3-only protein

Adam Oberstein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis

Abhinav Diwan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E. Czabotar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

BH3-only proteins in tumorigenesis and malignant melanoma

A. M. Karst et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biochemistry & Molecular Biology

Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70

Hirotaka Matsui et al.

MOLECULAR CELL (2007)

Article Hematology

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

Cinta Mestre-Escorihuela et al.

BLOOD (2007)

Article Rheumatology

Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

John C. Scatizzi et al.

ARTHRITIS RESEARCH & THERAPY (2007)

Article Biochemistry & Molecular Biology

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

A. Hamacher-Brady et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

5-Aza-2′-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer)

Zunyan Dai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Oncology

BH3-only proteins: Integrated control point of apoptosis

Tsukasa Shibue et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

Article Biochemistry & Molecular Biology

Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells

Pedro J. Real et al.

FEBS LETTERS (2006)

Article Biochemistry & Molecular Biology

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways

Tsukasa Shibue et al.

EMBO JOURNAL (2006)

Article Cell Biology

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Shida Yousefi et al.

NATURE CELL BIOLOGY (2006)

Article Oncology

The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD

Roland Schmitz et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

Article Rheumatology

Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages

Hongtao Liu et al.

ARTHRITIS AND RHEUMATISM (2006)

Article Immunology

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

Han You et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Biochemistry & Molecular Biology

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

I Sturm et al.

CELL DEATH AND DIFFERENTIATION (2006)

Article Biochemistry & Molecular Biology

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles

AY Denisov et al.

BIOCHEMISTRY (2006)

Review Cell Biology

Life in the balance: how BH3-only proteins induce apoptosis

SN Willis et al.

CURRENT OPINION IN CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Regulation of apoptosis: uncovering the binding determinants

MG Hinds et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)

Article Clinical Neurology

Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas

M Nakamura et al.

ACTA NEUROPATHOLOGICA (2005)

Article Biochemistry & Molecular Biology

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

S Pattingre et al.

Article Biochemistry & Molecular Biology

Proapoptotic BID is an ATM effector in the DNA-damage response

I Kamer et al.

Article Biochemistry & Molecular Biology

A role for proapoptotic BID in the DNA-damage response

SS Zinkel et al.

Article Multidisciplinary Sciences

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

T Oltersdorf et al.

NATURE (2005)

Article Pathology

Deletion of bid impedes cell proliferation and hepatic carcinogenesis

L Bai et al.

AMERICAN JOURNAL OF PATHOLOGY (2005)

Article Biochemistry & Molecular Biology

C-elegans ced-13 can promote apoptosis and is induced in response to DNA damage

B Schumacher et al.

CELL DEATH AND DIFFERENTIATION (2005)

Letter Cell Biology

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex

JIJ Leu et al.

NATURE CELL BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Membrane lipids and cell death: an overview

IM Cristea et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2004)

Article Multidisciplinary Sciences

Bim is a suppressor of Myc-induced mouse B cell leukemia

A Egle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Oncology

Inactivating mutation of the pro-apoptotic gene BID in gastric cancer

JH Lee et al.

JOURNAL OF PATHOLOGY (2004)

Article Biochemistry & Molecular Biology

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

T Hershko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis

JY Hur et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Three novel bid proteins generated by alternative splicing of the human bid gene

SA Renshaw et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

AJ García-Sáez et al.

BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion

K Nakajima et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Tissue transglutaminase is a multifunctional BH3-only protein

C Rodolfo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner

CG Broustas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

H Harada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Genetics & Heredity

Comparative genomics: the evolutionary history of the Bcl-2 family

C Lanave et al.

Article Biochemistry & Molecular Biology

FoxO3a transcriptional regulation of bim controls apoptosis in paclitaxel-treated breast cancer cell lines

A Sunters et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death

YW Seo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa

A Villunger et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

H Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Cell Biology

Integral role of Noxa in p53-mediated apoptotic response

T Shibue et al.

GENES & DEVELOPMENT (2003)

Article Oncology

Mutations of the BIK gene in human peripheral B-cell lymphomas

V Arena et al.

GENES CHROMOSOMES & CANCER (2003)

Article Multidisciplinary Sciences

Bad-deficient mice develop diffuse large B cell lymphoma

AM Ranger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Biochemistry & Molecular Biology

Dynamics of mitochondrial morphology in healthy cells and during apoptosis

M Karbowski et al.

CELL DEATH AND DIFFERENTIATION (2003)

Article Immunology

Mutational analysis of Noxa gene in human cancers

SH Lee et al.

APMIS (2003)

Article Biochemistry & Molecular Biology

Mitochondrial apoptotic pathways induced by Drosophila programmed cell death regulators

C Clavería et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Biochemistry & Molecular Biology

p53 has a direct apoptogenic role at the mitochondria

M Mihara et al.

MOLECULAR CELL (2003)

Article Multidisciplinary Sciences

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

J Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Cell Biology

Transglutaminases: Crosslinking enzymes with pleiotropic functions

L Lorand et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Cell Biology

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

SS Zinkel et al.

GENES & DEVELOPMENT (2003)

Article Biochemistry & Molecular Biology

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

MG Yussman et al.

NATURE MEDICINE (2002)

Article Biochemistry & Molecular Biology

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

M Marani et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage

K Yoshida et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Review Biochemistry & Molecular Biology

Keeping killers on a tight leash: transcriptional and posttranslational control of the pro-apoptotic activity of BH3-only proteins

H Puthalakath et al.

CELL DEATH AND DIFFERENTIATION (2002)

Article Biochemistry & Molecular Biology

tBID homooligomerizes in the mitochondrial membrane to induce apoptosis

M Grinberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Chemistry, Medicinal

Discovery of small-molecule inhibitors of bcl-2 through structure-based computer screening

IJ Enyedy et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity

MD Esposti et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Multidisciplinary Sciences

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

JW Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

BAD/BCL-xL heterodimerization leads to bypass of G0/G1 arrest

A Chattopadhyay et al.

ONCOGENE (2001)

Article Biochemistry & Molecular Biology

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

A Kihara et al.

EMBO REPORTS (2001)

Article Biochemistry & Molecular Biology

PUMA induces the rapid apoptosis of colorectal cancer cells

J Yu et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

PUMA, a novel proapoptotic gene, is induced by p53

K Nakano et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

Phosphorylation of the pro-apoptotic protein BIK - Mapping of phosphorylation sites and effect on apoptosis

S Verma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Cell Biology

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

SP Tzung et al.

NATURE CELL BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

B Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

KO Tan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Biochemistry & Molecular Biology

BH3-Only proteins - Essential initiators of apoptotic cell death

DCS Huang et al.

Article Biochemistry & Molecular Biology

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

AM Petros et al.

PROTEIN SCIENCE (2000)

Article Biochemistry & Molecular Biology

NMR studies of the anti-apoptotic protein Bcl-xL in micelles

JA Losonczi et al.

BIOCHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155

XM Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

RK Bruick

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

C Vande Velde et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Biochemistry & Molecular Biology

Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death

CD Bingle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Human DNA damage checkpoint protein hRAD9 is a 3′ to 5′ exonuclease

T Bessho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm

SC Tsai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

S Shimizu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)