Journal
ONCOGENE
Volume 27, Issue 16, Pages 2263-2275Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2008.20
Keywords
FOXO; forkhead transcription factors; 14-3-3 protein; phosphorylation; acetylation; ubiquitination
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The FOXO subgroup of forkhead transcription factors plays a central role in cell-cycle control, differentiation, metabolism control, stress response and apoptosis. Therefore, the function of these important molecules is tightly controlled by a wide range of protein-protein interactions and posttranslational modifications including phosphorylation, acetylation and ubiquitination. The mechanisms by which these processes regulate FOXO activity are mostly elusive. This review focuses on recent advances in structural studies of forkhead transcription factors and the insights they provide into the mechanism of DNA recognition. On the basis of these data, we discuss structural aspects of protein-protein interactions and posttranslational modi. cations that target the forkhead domain and the nuclear localization signal of FOXO proteins.
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