Journal
ONCOGENE
Volume 27, Issue 37, Pages 5069-5074Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2008.141
Keywords
CRD-BP; beta-TrCP; mRNA stability; melanoma; Wnt/beta-catenin signaling; NF-kappa B
Funding
- NCI [CA121851]
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Wnt/beta-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/beta-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of beta-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-kappa B) signaling. Knockdown of CRD-BP inhibits NF-kappa B activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.
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