Journal
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
Volume 17, Issue 12, Pages 627-635Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/omi.2013.0031
Keywords
-
Funding
- UO1 grants [HL68734, HL68676, HL68790, HL68920, HL68955]
- Measurement to Understand Re-Classification of Disease of Cabarrus and Kannapolis (MURDOCK) Study
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [1UL1 RR024128-01]
- NIH Roadmap for Medical Research
Ask authors/readers for more resources
In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this possibility, we performed a cross-sectional analysis of fasting plasma levels of 69 small-molecule metabolites and 13 metabolic hormones in 500 overweight/obese adults who participated in the Weight Loss Maintenance trial. Principal-components analysis (PCA) was used for reduction of metabolite data. Race and sex-stratified comparisons of metabolite factors and metabolic hormones were performed. African Americans represented 37.4% of the study participants, and females 63.0%. Of thirteen metabolite factors identified, three differed by race and sex: levels of factor 3 (branched-chain amino acids and related metabolites, p<0.0001), factor 6 (long-chain acylcarnitines, p<0.01), and factor 2 (medium-chain dicarboxylated acylcarnitines, p<0.0001) were higher in males vs. females; factor 6 levels were higher in Caucasians vs. African Americans (p<0.0001). Significant differences were also observed in hormones regulating body weight homeostasis. Among overweight/obese adults, there are significant race and sex differences in small-molecule metabolites and metabolic hormones; these differences may contribute to risk factor heterogeneity across race and sex subgroups and should be considered in future investigations with circulating metabolites and metabolic hormones.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available