Journal
OLIGONUCLEOTIDES
Volume 19, Issue 2, Pages 179-189Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/oli.2008.0167
Keywords
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Funding
- National Institute of Advanced Industrial Science and Technology
- Research for Promoting Technological Seeds of JST
- PRESTO of JST [19036026]
- Strategic Research [K20008]
- Grants-in-Aid for Scientific Research [21370047] Funding Source: KAKEN
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Nuclear magnetic resonance (NMR) studies have shown that RNA/DNA oligomers with GGA repeat sequences contain unique G-quadruplex structures in the presence of K+ or Na+ ions. In this study, we used microchip electrophoresis to study the structure of an RNA aptamer against bovine prion protein that possessed four GGA-triplet repeats (wt2). We analyzed the structural changes and characterized dimer formation of the aptamer. Mutational, circular dichroism, and one-dimensional NMR studies of wt2 revealed that K+ ions induce wt2 to assume a thermostable dimer in an intramolecular G-quadruplex with parallel orientation.
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