Journal
OCULAR SURFACE
Volume 10, Issue 1, Pages 2-14Publisher
ELSEVIER
DOI: 10.1016/j.jtos.2012.01.002
Keywords
allodynia; corneal pain; dry eye; hyperalgesia; inflammation; nociceptive network; pain
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Funding
- Boston Foundation for Sight
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The traditional model of dry eye disease based on tear deficiency has presented us with many unanswered questions. Recent studies support the notion that dry eyelike symptoms represent non-specific corneal pain and provide new insights into the mechanisms that sustain the integrity of the optical tear layer. Thus, this enigmatic disease can be viewed with a new perspective, which involves the dysfunctional corneal pain system as a central pathogenetic feature of a series of disorders collectively known today as dry eye.
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