Journal
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 68, Issue 7, Pages 494-501Publisher
B M J PUBLISHING GROUP
DOI: 10.1136/oem.2010.058065
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Funding
- Economic and Social Research Council
- National Birthday Trust Fund
- Institute of Child Health (University College London)
- National Foundation for Educational Research
- Department of Health
- Department of Health and Social Security
- Department of Education and Science
- Department of Employment
- Department of the Environment
- Manpower Services Commission
- Department of Social Security
- Transport and Road Research Laboratory
- Health and Safety Executive
- National Institute for Child Health and Development, United States of America
- Asthma UK [ID 07/32]
- Asthma UK [07/032] Funding Source: researchfish
- Medical Research Council [G0801056B] Funding Source: researchfish
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Objectives To investigate whether prior symptoms of allergic disease influence first job undertaken on leaving school. Methods The study included 5020 members of the 1958 British birth cohort who provided a job history (including start dates) at age 33 and for whom information on allergic disease in childhood and adolescence was reported by parents at ages 7, 11 and 16. Occupational group (high risk, low risk, reference) was based on first job and its probable asthma risk. Results With occupational group defined using only job title, the RR of taking a high risk over a reference level job was an estimated 30% (RR ratio (RRR) 0.70; 95% CI 0.56 to 0.88) lower among those with than without prior reported symptoms of hay fever/allergic rhinitis but an estimated 60% (RRR 1.60; 1.17 to 2.19) higher among those with symptoms of asthma/wheezy bronchitis in adolescence compared to those with no history of asthma/wheezy bronchitis. With occupational group defined using an asthma specific job exposure matrix, a similar association was observed for prior hay fever/allergic rhinitis (RRR 0.77; 0.62 to 0.96) but not for asthma/wheezy bronchitis (RRR 1.18; 0.85 to 1.64). There was no evidence of an association between prior eczema and occupational group of first job. Conclusion Whether our findings indicate avoidance or residual confounding, it would be prudent for future studies of occupation and the incidence or recurrence of asthma in adult life to adjust for any previous history of hay fever/allergic rhinitis.
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