Journal
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
Volume 35, Issue 4, Pages 633-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ogc.2008.09.004
Keywords
Adolescence; Human papillomavirus; Low-grade and high-grade squamous intraepithelial lesions; Cervical intraepithelial neoplasia I, II, and III
Categories
Funding
- NCI NIH HHS [R37 CA051323, R01 CA087905, R01 CA087905-05S1, R37 CA051323-19] Funding Source: Medline
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Adolescents have been shown to have the highest rates of human papillomavirus (HPV) infection. The cause is likely a combination of sexual risk behavior and biologic vulnerability. Most HPV and its associated abnormal cytology are transient, with frequent clearance of HPV and the lesion. These findings have resulted in new strategies, including observation, for adolescents who have abnormal cytology. For cytologic atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions, adolescents should be followed with cytology at 1-year intervals for up to 2 years before referral for colposcopy is necessary. For biopsy-proved cervical intraepithelial neoplasia. (CIN) 1, management is similar, with yearly cytology indefinitely or until high-grade squamous intraepithelial lesions or CIN 2,3 develops. CIN 2,3 in compliant adolescents can be managed with 6-month cytology and colposcopy up to 2 years.
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