Journal
OBESITY SURGERY
Volume 24, Issue 2, Pages 310-323Publisher
SPRINGER
DOI: 10.1007/s11695-013-1137-2
Keywords
Duodenal-jejunal bypass liner; Obesity; Type 2 diabetes mellitus; Endoscopic techniques
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Funding
- European Commission [20112301]
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This systematic literature review applies the GRADE approach to evaluate the efficacy and safety of the duodenal-jejunal bypass liner (DJBL) for the treatment of (a) patients with obesity a parts per thousand yenaEuro parts per thousand grade II (with comorbidities) and (b) patients with type 2 diabetes mellitus + obesity a parts per thousand yenaEuro parts per thousand grade I. We included ten studies with a total of 342 patients that primarily investigated a prototype of the DJBL. In high-grade obese patients, short-term excess weight loss was observed. For the remaining patient-relevant endpoints and patient populations, evidence was either not available or ambiguous. Complications (mostly minor) occurred in 64-100 % of DJBL patients compared to 0-27 % in the control groups. Gastrointestinal bleeding was observed in 4 % of patients. We do not yet recommend the device for routine use.
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