Journal
OBESITY REVIEWS
Volume 13, Issue 8, Pages 733-743Publisher
WILEY
DOI: 10.1111/j.1467-789X.2012.00997.x
Keywords
Foxp3; kidney; leptin; nephrology
Categories
Funding
- Brazilian Foundation - FAPESP [09/50450-7, 2010/52180-4, 2012/02270-2, 07/07139-3]
- International Associated Laboratory in Renal Immunopathology (CNPq/Inserm)
- INCT Complex Fluids
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/50450-7] Funding Source: FAPESP
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Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.
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