Journal
OBESITY RESEARCH & CLINICAL PRACTICE
Volume 8, Issue 6, Pages E540-E548Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.orcp.2013.12.005
Keywords
Obesity; Heart failure; Mechanisms
Categories
Funding
- National Heart Lung and Blood Institute [5 T32 HL087730-03]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL087730, R01HL104199] Funding Source: NIH RePORTER
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Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may result in heart failure by inducing haemodynamic and myocardial changes that lead to cardiac dysfunction, or due to an increased predisposition to other heart failure risk factors. Direct cardiac lipotoxicity has been described where lipid accumulation in the heart results in cardiac dysfunction inexplicable of other heart failure risk factors. In this overview, we discussed various pathophysiological mechanisms that could lead to heart failure in obesity, including the molecular mechanisms underlying cardiac lipotoxicity. We defined the obesity paradox and enumerated various premises for the paradoxical associations observed in the relationship between obesity and heart failure. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
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