Journal
OBESITY RESEARCH & CLINICAL PRACTICE
Volume 8, Issue 4, Pages E339-E349Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.orcp.2013.10.005
Keywords
Obesity; Diabetes mellitus type 2; Testosterone; Waist circumference; Weight loss
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Background: Treatment of obesity with diet and exercise may have short-term success but longer-term maintenance of weight loss is less successful. Obesity is associated with a reduction of serum testosterone, and, vice versa, a reduction in serum testosterone is associated with obesity and features of the metabolic syndrome. Objective: To investigate whether restoring serum testosterone to normal in hypogonadal obese men is beneficial with regard to weight loss and improvement of the metabolic syndrome. Methods: A prospective registry accumulated to 181 men over five years (mean serum testosterone 10.06 +/- 1.3 nmol/L (N > 12.1), body mass index (BMI) >= 30 kg/m(2). Of these men, 72 had diabetes mellitus type 2. All received parenteral testosterone undecanoate 1000 mg/12 weeks for up to five years. Results: Waist circumference (cm) decreased from 111.2 +/- 7.54 to 100.46 +/- 7.1, weight (kg) from 114.71 +/- 11.59 to 93.2 +/- 8.49, BMI (kg/m(2)) from 36.72 +/- 3.72 to 30.2 +/- 2.59 (all variables statistically significant vs. baseline (p < 0.0001) and each year compared to the previous year (p < 0.0001)). In the 72 diabetic men, waist circumference (cm) decreased from 112.93 +/- 7.16 to 101.48 +/- 7.24, weight (kg) from 116.94 +/- 11.62 to 94.42 +/- 9.42, BMI (kg/m(2)) from 37.71 +/- 3.5 to 30.95 +/- 2.69 (all variables statistically significant vs. baseline (p < 0.0001) and each year compared to the previous year (p < 0.0001)). In all men serum glucose, HbA(1c), lipid profiles and blood pressure improved significantly. Testosterone treatment as assessed by hemoglobin, hematocrit, serum prostate specific antigen (PSA) and occurrence of prostate cancer was acceptably safe. Conclusions: Normalizing serum testosterone in obese hypogonadal men, also in those with diabetes type 2, improved their metabolic state. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
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