Journal
OBESITY RESEARCH & CLINICAL PRACTICE
Volume 5, Issue 2, Pages E143-E150Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.orcp.2011.01.001
Keywords
Aerobic capacity; Fat in liver; Lipid-rich skeletal muscle; Visceral fat; Insulin resistance
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Funding
- Japanese Government's Ministry of Education, Culture, Sports, Science and Technology [A19200049]
- Global FU Program grant from Fukuoka University
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Aim: This study evaluated the relationships between body fat accumulation, aerobic capacity and insulin resistance (HOMA-IR) in 61 Japanese participants. Method: The participants were middle-aged to elderly (age: 33-73; BMI: 21.6-38.5). Body fat mass (FM) was evaluated by hydrostatic weighing. Computed tomography was used to evaluate visceral and subcutaneous fat areas (VFA and SFA), liver to spleen ratio (L/S), and low-density muscle area (LDMA). To assess aerobic capacity, VO2 at the lactate threshold (VO2@LT) and VO2 (peak) were measured using a bicycle ergometer. Results: FM, VFA, SFA, LDMA and L/S significantly correlated with HOMA-IR, but VO2@LT and VO2 (peak) did not. Analysis of covariance after adjustment for VFA or other body fat distribution and aerobic capacity showed that HOMA-IR had a significant linear trend across the tertile groups of L/S. However, for FM, VFA, SFA, LDMA and VO2@LT or VO2 (peak), no significant trend was observed between the tertiles and insulin resistance. Conclusions: Ectopic fat deposition in the liver may influence insulin resistance independently of other body fat accumulation and aerobic capacity in Japanese participants. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
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