Journal
OBESITY RESEARCH & CLINICAL PRACTICE
Volume 2, Issue 3, Pages 159-169Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.orcp.2008.04.003
Keywords
Lactobacillus paracasei ST11; White adipose tissue; Lipolysis; Autonomic nerves; Thermogenesis
Categories
Ask authors/readers for more resources
In a recent study, we obtained some evidences that probiotic strain Lactobacillus affects the autonomic nerve activities and regulates blood glucose and cardiovascular function. In the study presented here, we found that long-term ingestion of the lactobacillus strain Lactobacillus paracasei ST11 (NCC2461) reduced body weight and abdominal fat weight. To investigate possible role of autonomic nerves in anti-obesity action of NCC2461, we examined the effects of intraduodenal (ID) injection of the lactobacillus strain L. paracasei ST11 (NCC2461) on sympathetic nerve activity innervating white adipose tissue (WAT-SNA) in urethane-anesthetized rats, and found that it accelerated WAT-SNA. Moreover, intraduodenal (ID) injection of NCC2461 increased in sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) and decreased in hepatic vagal nerve activity (HVNA). In addition, using conscious rats, we examined the effects of intra-gastric (IG) injection of NCC2461 on lipolysis and BAT thermogenesis, and observed that it clearly elevated the plasma FFA level, BAT temperature and abdominal temperature. Thus, these data suggest that the NCC2461 affects autonomic nerves, enhances lipolysis, and reduces body weight in rats. (c) 2008 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. Alt rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available