Journal
TALANTA
Volume 145, Issue -, Pages 43-54Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2015.04.068
Keywords
Low-cost bioassays; Paper-based microfluidic lab-on-a-chip; Paper hybrid microfluidic platform; Disease diagnosis; Food safety analysis
Categories
Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) [R21AI107415]
- National Institute of General Medical Sciences of the NIH [SC2GM105584]
- IDR Program at the University of Texas at El Paso (UTEP)
- NIH RCMI Pilot Grant
- Key (Key grant) Project of Chinese Ministry of Education [313045]
- International Science & Technology Cooperation Program of China [2013DFG02930]
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Low-cost assays have broad applications ranging from human health diagnostics and food safety inspection to environmental analysis. Hence, low-cost assays are especially attractive for rural areas and developing countries, where financial resources are limited. Recently, paper-based microfluidic devices have emerged as a low-cost platform which greatly accelerates the point of care (POC) analysis in low-resource settings. This paper reviews recent advances of low-cost bioanalysis on paper-based microfluidic platforms, including fully paper-based and paper hybrid microfluidic platforms. In this review paper, we first summarized the fabrication techniques of fully paper-based microfluidic platforms, followed with their applications in human health diagnostics and food safety analysis. Then we highlighted paper hybrid microfluidic platforms and their applications, because hybrid platforms could draw benefits from multiple device substrates. Finally, we discussed the current limitations and perspective trends of paper-based microfluidic platforms for low-cost assays. (C) 2015 Elsevier B.V. All rights reserved.
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