Journal
TALANTA
Volume 132, Issue -, Pages 443-450Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2014.08.046
Keywords
Quality control; Veterinary drug residues; Matrix effects; Validation; Ion suppression; Control charts; Antibiotics; Sulfonamides
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Funding
- Brazilian Ministry of Agriculture (MAPA)
- Generalitat de Catalunya (Consolidated Research Group: Water and Soil Quality Unit) [2014-SGR-418]
- CAPES [PVE 163/2012]
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In residue analysis of veterinary drugs in foodstuff, matrix effects are one of the most critical points. This work present a discuss considering approaches used to estimate, minimize and monitoring matrix effects in bioanalytical methods. Qualitative and quantitative methods for estimation of matrix effects such as post-column infusion, slopes ratios analysis, calibration curves (mathematical and statistical analysis) and control chart monitoring are discussed using real data. Matrix effects varying in a wide range depending of the analyte and the sample preparation method: pressurized liquid extraction for liver samples show matrix effects from 15.5 to 59.2% while a ultrasound-assisted extraction provide values from 21.7 to 64.3%. The matrix influence was also evaluated: for sulfamethazine analysis, losses of signal were varying from -37 to -96% for fish and eggs, respectively. Advantages and drawbacks are also discussed considering a workflow for matrix effects assessment proposed and applied to real data from sulfonamides residues analysis. (C) 2014 Elsevier B.V. All rights reserved.
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