Journal
TALANTA
Volume 131, Issue -, Pages 661-665Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2014.08.042
Keywords
Fe3O4/SiO2/Gd2O(CO3)(2); Nanoparticles; Magnetic resonance imaging; Contrast agents
Categories
Funding
- Shanghai Municipal Education Commission [12ZZ041]
- NSFC [61177011]
- Shanghai Municipal Commission for Science and Technology [11JC1403800]
- PCSIRT
- NCET
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Core/shell/shell structured Fe3O4/SiO2/Cd2O(CO3)(2) nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)(2) and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd3+ enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd3+ and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)(2) nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications. (C) 2014 Elsevier B.V. All rights reserved.
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